|Updates from the lab of
Dr. Evangelos Kiskinis
The lab of Dr. Evangelos Kiskinis shares four remarkable scientific collaborations:
1. Urate-elevating therapy: An ongoing collaboration with two teams of researchers at Massachusetts General Hospital, Harvard Medical School, led by Michael Schwarzschild, MD, PhD, and Ghazaleh Sadri-Vakili, MS, PhD, is centered on deciphering the potential therapeutic effects of urate for treating ALS patient motor neurons. Urate appears to have a protective role against glutamate excitotoxicity and protects mutant SOD1 cells.
2. A major joint investigation with Alex Meissner, PhD, at Harvard University is focused on the potential role for DNA methylation on the development and function of motor neurons both in health and in ALS disease.
3. Neuronal Excitability Project: Work with the Cohen and Eggan groups at Harvard University continues on a project which probes neuronal excitability alterations in ALS using a novel optogenetic approach. This study is currently under review for publication.
4. A new collaboration with the lab of Dr. Chris Donnelly at the Live Like Lou Center for ALS Research, Brain Institute, University of Pittsburgh, is studying the effects of C9orf72 mutations on nucleo-cytoplasmic transport. Learn more about the lab of Dr. Kiskinis here >>